As corn and soy feed ingredients have experienced increased price volatility, the cost savings associated with maximizing the use of methionine activity in animals’ diets have increased. Nutrition experts seeking to improve feed efficiency and reduce feed cost routinely turn to HMTBa as their solution. HMTBa is a naturally-occurring methionine precursor that has been found in yeast, plants, chickens and other organisms. The growth in demand for the HMTBa molecule is nearly half of the global methionine market.

Since the first sale of ALIMET in 1979, researchers have sought to understand the total value of HMTBa. The knowledge gained over the past three decades in the area of bioavailability and strength of the HMTBa molecule in this area have contributed to the success of Novus -branded methionine solutions.

Chris Knight, vice president of research at Novus explains, “Over the years, concerns have been expressed that conversion of the HMTBa molecule to methionine was less efficient than other sources.

However, after more than three decades of commercial application, scientific scrutiny and industry review we have learned that the molecule is 100 percent bioavailable.”

In commercial conditions, the unique HMTBa molecule provides competitive advantages over DL-Methionine (DLM), such as animals’ improved performance during times of heat stress, health benefits of an organic acid and reduced environmental impact through reduced nitrogen excretion.


These benefits to poultry diets have been long-supported by industry and academia. The expansion to ruminant applications has shown even greater value when supplemented at proper inclusion rates.

“The rumen bypass value of HMTBa can’t be overlooked when formulating diets for the dairy cow and supplementing beef cattle on pasture,” reports Mercedes Vazquez-Añon, senior research director at Novus.

“While DLM is degraded rapidly in the rumen, providing little to no benefit to the animal, HMTBa has a ruminal escape value of approximately 40 percent. This has been verified by numerous published, peer-reviewed papers since 1998.

The ruminal escape of HMTBa means the molecule can be absorbed by diffusion along the digestive tract. Studies have shown that HMTBa benefits are seen in dairy cows by improving production of milk components, and in beef cattle with more weight per calf and improved reproduction.” PD

—From Novus news release