Selenium deficiency in beef cattle

Beef cattle only require 0.1 parts per million (ppm) of Se in the total diet (not the mineral supplement). Although plants in some parts of the country can contain toxic levels of Se, forages grown in many parts of the country do not contain adequate levels of Se for optimum animal performance.

Roy Burris

What is selenium?

Selenium is a trace element (mineral) which is incorporated into proteins to make selenoproteins, which are important antioxidant enzymes. One of the most important of these is an enzyme known as glutathione peroxidase.

The antioxidant properties of Se-inclusive enzyme systems helps prevent cellular damage from free radicals. Free radicals are natural byproducts of oxygen metabolism and a functional immune system that may contribute to the development of health problems.

What are the deficiency symptoms?

The classic clinical deficiency of Se and vitamin E is white-muscle disease, which is myodegeneration of the heart muscle. In this disease, white sections are observed in heart muscle.

However, as all good managers know, there are a lot of “unseen” problems in a nutritional deficiency before cattle exhibit clinical signs – such as decreased immunity, growth and fertility.

As indicated in Figure 1, immunity, growth and reproduction can be impaired before clinical symptoms appear. For example, cattle with a compromised immune system may not mount an immune response despite being vaccinated for various diseases.

Immunity, growth and reproduction can be impaired before clinical symptoms appear

Do not wait until clinical signs appear to supply trace minerals to cattle diets.

Dietary sources of selenium

Plants (forage and grain crops) are the major dietary source of Se. The Se content of plants is influenced by the concentration and availability of Se in the soil. Feedstuffs grown in Se-deficient areas are poor sources of Se.

Areas in the U.S. like the Northwest, Great Lakes region, West Coast, Eastern seaboard and the southeast U.S. may have low-Se soils where deficiencies can be a problem.

Beef cattle require 0.1 ppm (mg/kg) of Se in the diet to meet their daily requirements. Much of the forages and grain grown in certain areas of the U.S. are at levels which allow those areas to be classified as low (where 80 percent of all forage and grain contains less than 0.05 ppm of Se). The Southeast (like Kentucky) is classified as low to variable.

However, beef cattle operations in this region seem to have a high percentage of Se-deficient (less than 0.08 ppm Se in whole blood) animals.

An important factor affecting Se content of forages is soil pH. In general, plants grown in acidic soil will absorb less Se than plants grown in alkaline soils. Another factor is the concentration of sulfur (S) in the soil.

Se and S are chemically similar and compete for absorption by the plant. Thus, high levels of S in the soil may lower the Se content of the forage. Sulfate fertilizers can decrease the Se content of plants, which may not hurt the plants but can have a detrimental effect on cattle that graze them.

How do we overcome low dietary levels of Se?

Cattle require 0.1 ppm Se in their diet to meet their daily requirement, so supplemental Se is needed for diets grown on low-Se soils. Supplemental Se is generally supplied to cattle in a free-choice salt/mineral supplement. The FDA allows for up to 120 ppm Se, regardless of source, to be added to the mineral supplement for free-choice feeding to provide a maximum of 3 mg per head daily.

Feedtags on mineral supplements will generally indicate the expected level of consumption, and Se is added to provide 3 mg at that level of intake. For example, at an indicated level of intake of 3 ounces per head per day, the mineral supplement may contain 35 ppm Se. At 4 ounces intake, the Se level would be reduced to 26 ppm to stay at the 3-mg-per-head daily level.

What about the form of Se?

Se is usually added to the feed in inorganic forms as sodium selenite or selenate. Se is usually found in plants combined with amino acids – selenomethionine and selenocysteine – so it is logical to wonder if these “organic” forms of Se might not be more available to the animal than the “inorganic” (like sodium selenite) form.

Recently, Se-enriched yeast, in which selenomethionine is the predominant form of Se, has become available and has been approved for use by the FDA. Sodium selenite is used primarily because it is less expensive. Organic forms of Se need to be more available or effective in order to be an economical alternative to sodium selenite.

Are there any advantages for organic Se?

Researchers at the Kentucky station conducted a trial with individually fed beef heifers which received no Se, inorganic Se (sodium selenite) or organic Se (Sel-Plex) at the 3-mg-per-head-per-day rate.

More Se was found in jugular whole blood, red blood cells and biopsied liver tissue of the heifers receiving either form of Se than in the unsupplemented heifers. However, organic Se animals had more Se in these tissues than calves which were receiving sodium selenite.

Analyses of liver tissue gene expression revealed that the content of at least 80 mRNA was affected by the form of Se.

Three Se supplement-dependent gene groups were identified: ISe-dependent, OSe-dependent and Se-form independent. Since the form of Se affects genetic expressions differently, it made sense to look at a mixture of the two forms – with 50 percent of the 3 mg per day coming from each source.

A long-term trial (224 days) was conducted with growing beef heifers to see what effect an equal blend of ISe and OSe would have on Se tissue concentrations. Calves received no Se, inorganic Se, organic Se or 1-to-1 mixture of OSe and ISe.

More Se was found in whole blood and liver of the calves receiving the mix or the organic Se than those receiving the inorganic Se – and all were greater than the controls.

Additional trials have been conducted, including a three-year study with cows on pasture with free individual access to one of the following treatments containing 35 ppm of Se – inorganic (sodium Selenite), organic (Sel-Plex) or a 1-to-1 combination of the two.

Cow Se treatment differentially affected both cow and suckling calf Se blood concentrations, resulting in adequate concentrations for all cows but inadequate concentrations for the calves of cows which received the inorganic Se (sodium selenite).

So what is your recommendation to avoid Se deficiency?

First, keep a good mineral mix available to all cattle at all times. In Se-deficient areas, I recommend we feed Se at the 3-mg level (maximum allowed by FDA). Based on our research, I would prefer that selenium be 50 percent sodium selenite and 50 percent organically derived (like Sel-Plex).

So if your cows consume 3 to 4 ounces of a good mineral supplement daily, it should contain 26 to 35 ppm Se with half from organic and half from inorganic forms of Se, since both forms elicit different responses in growth and immunity.

Anything else?

Remember that mineral supplements must be consumed at the levels for which they are formulated. Keep them available constantly and resist the urge to add plain white salt to cut back consumption and “save” money. Don’t do it.

References omitted due to space but are available upon request. Click here to email an editor.

PHOTO: Intensive research has been conducted at the University of Kentucky both in confinement and on pasture to study selenium supplementation to beef cattle diets. Photo provided by Roy Burris.